It'd be nice if it would be possible to remove the HostSetters directive from the anope configuration file then make it so you can add HostSetters via OperServ commands like you do services admins and opers. (ie. /msg OperServ HOSTSETTER ADD ...). Then you can just store HostSetters in the db files like services admin and opers. A directive would also be nice though to determine who could add HostSetters. (ie. 1=IRCops, 2=Services Opers, 3=Services Admins, 4=Services Root).
Just a thought.