Well, as far as I can tell, at least with Anope 1.9.1 and InspIRCd 1.2, Anope does nothing if a client is using a pseudo-client's nick, but Insp sends an SVSNICK to change the pseudo-client to it's UID, and even if the client changes nicks later, Anope doesn't change the pseudo-client back. It should be noted that Anope's inspircd12 apparently doesn't use Q:lines for the clients, Anope only sends UID commands to the server. I haven't tested Anope 1.8.x or a different protocol module yet. If anyone else can, make sure you run Anope in debug mode and can provide a log of what Anope sends and receives in the case of someone, say, using OperServ. (Assuming that OperServ is still named as such in the config)